Hypoglaucum the anticancer effect of
hypoglaucum (six vines, purple vine, purple skin, torch flower, 721) Tripterygium hypoglaucum (Le, vl) Hutch product is Celastraceae wilfordii (Tripterygium) species , isolated from the three chemical composition that Triptolide (Triptolide, Triptolide), Tripterygium B (Tripterygium hydroxyl lactone, Tripdiolide), Thunder and ketone (Tripterygium carbon lactone, triptonide), as terpenoids . [trait] Triptolide, melting point 226-227 degrees. hydroxyl lactone, mp 210-211 degrees. carbon lactone, mp 251-252 degrees.
[Function and use] the product of rheumatoid arthritis a certain effect. civil Useful to treat cancer experience. rethen factors A, B, C on experimental tumors have high activity, reported in 1977 from domestic hypoglaucum Tripterygium isolated elements A, the animal experiments, 0.25 mg / kg of mouse L615 has a good effect. Nations hypoglaucum trial with 32 patients with nasopharyngeal carcinoma, lung cancer, 16 cases were easing.
Thunder Teng (China Drug Chi) [synonym] yellow vine roots xanthate, the water grass that causes, Ussuriensis Maxim, vegetable insecticide, South snake root, triangular flowers, dry flower Wo (Hunan drugs chi) Huang Teng wood (Guangxi Drug List), red medicine, red violet root, Huang Teng Tso (Jiangxi Herbal Handbook).
[base of the original] to Celastraceae plants Thunder Teng's roots, leaves and flowers. [of the original plants] Thunder Teng Teng Yripterygium wilfordii Hook.f. climbing this, 2-3 meters high. branchlets reddish-brown , angular, with a long round of small tumor-like protrusions and rust-brown hair. Single Leaves alternate, sub-coriaceous, ovate, oval or broad oval, 5-10 cm long, 3-5 cm wide, acuminate tip, base rounded or circular wedge, margin serrulate, smooth above, pale green below, the main vein and lateral veins in the leaf tip on both sides are elevated. clock Shangshu rusty brown pubescent, petiole about 5 mm, surface dense rusty-brown short hair. flowers small, white, axillary or terminal for the large cone of inflorescence, calyx 5 crack, petals 5, oblong, stamens 5, filaments wide near base,UGG shoes, with faceplate born in cup edge of the upper ovary, triangular shape, style short, stigma head-like, winged, membranous, first tip was cut off a round or shaped, base rounded, about 1.5 cm, 1 cm wide, brown, 3 edge, the central one usually has seeds. seed slender, linear, flowering from May to June, fruit from August to September. born in a little fat shady, damp slopes, valleys, stream and secondary thicket of bushes. Division of Zhejiang, Jiangxi, Anhui, Hunan, Guangdong, Fujian and Taiwan.
[acquisition] summer and autumn harvest.
[components] Root with Tripterygium Alkali (Wilfordine), Tripterygium throwing base (wiforine), Tripterygium Jin alkali (Wilforgine), Tripterygium spring base (Wilfortrine), and in TW by alkali (WILFORZINE) and other alkaloids. In addition, triptolide also with MECO (Calastro), Euonymus alcohol, Triptolide and glucose, tannin, etc..
[Pharmacology] insecticidal effect, Tripterygium invasion of liquid water and ethanol extract were poisoned pear leaves and leaf-roller moth caterpillars satellite capacity. but its petroleum ether, ether or chloroform extract, there is no insecticide capabilities.
[toxic] triptolide on the toxicity of different kinds of animals, its people, dogs, pigs and insects very toxic, poisoning or even death can occur, but sheep, rabbits, cats, rats, fish Quewu toxicity. wilfordii on the role of the body there are two: one is to stimulate the local gastrointestinal effect, two for the absorption of the central nervous system (including the thalamus, midbrain , medulla oblongata, cerebellum and spinal cord) damage,cheap UGG boots, and cause liver, heart bleeding and necrosis. It is said that the main toxic animals Teng Thunder Heart, on the other smooth muscle and skeletal muscle are also toxic, the cause of death for the poisoning. poisoning acute measures induce vomiting, gastric lavage, enema, catharsis and other general method, using sheep blood or rabbit stomach biological detoxification methods leaching solution has not been determined. wilfordii toxic components can be used ether extraction, but after reduction, toxicity disappeared.
[of taste] side] 1: treatment of rheumatoid arthritis: Tripterygium roots, leaves, pounded to external application, after half an hour to go, otherwise the bubble . xylem slices dry. each with four money, add water 2500 ml, the text gently for (not stamped) 3-4 hours, take brown liquid 250 ml, morning and evening hours service .3-4 day cycle. have treated all types of leprosy Reaction of 167 cases (including 27 cases of nodular type, tumor type 140 cases), were taking control of symptoms after 2-3 doses .2: treatment of rheumatoid arthritis: use Tripterygium (take xylem, France ibid.) 5 money 400 ml water, the text gently for 2 hours (not stamped), with 150 ml of liquid residue taken together with 100 ml of water to cook, mix 2 minutes morning and evening service, 7-10 days as a course of treatment discontinuation among 2 - 3 days, treatment of 50 cases, drug treatment courses ranging from 1-20, mostly 5-6 treatment. 44 patients with varying degrees of improvement or remission .3: treatment of tuberculosis and other chronic lung diseases: in the autumn of taken root, washed and dried, chopped. 31.2 per 1000 ml of water Clay Public Tenga to be suffering slow fire and simmer till 500 ml (per 10 ml to 0.62 g crude drug) Serve. start 3 times a day, every 15 -20 ml orally, as a course of treatment a week later, as the condition and physical condition of patients, the dose may increase or decrease slightly, but not easily more than 10-25 ml per dose. If no significant medication side effects, they can still extend the medication time, but taking too long to be short-term withdrawal, general medicine 15-20 days, stop for 5-7 days. After treatment 99 patients, most of the patients after taking the cough, expectoration, fever and asthma symptoms in varying degrees, to reduce , the treatment prescribed dose of medication, basically no side effects, if the body is weak, could have a vicious, cold chills, gastrointestinal discomfort and side effects of .4: poisoning and detoxication: Tripterygium is a highly toxic drug, especially on the skin highly toxic, the use should be strictly net on the skin stripped, including the double skin and the skin every part of the tree.
units, according to the study of the role of triptolide on the body there are two, one for the partial gastrointestinal tract stimulation, one for the absorption of the central nervous system, including the thalamus, midbrain, medulla oblongata, cerebellum and spinal cord damage. and can cause liver, heart bleeding and necrosis. clinical manifestations of general poisoning symptoms dizziness, palpitations , weakness, nausea, vomiting, abdominal pain, diarrhea, liver pain, fecal blood, etc.. as a precautionary measure, to the people with heart, liver, kidney, stomach and other organic diseases of the patients and pregnant women should be disabled. on the governance process nausea vomiting, abdominal pain, bloating, liver pain, urinary protein and appear abnormal serum aminotransferase should be discontinued immediately. poisoning the general first-aid measures, in addition to vomiting gastric lavage, enema, catharsis, the available service of fresh carrot juice 4 2,UGG boots clearanc, or 8 two-ton service radish seed, also available fresh leek juice or tea, sheep blood,cheap UGG boots, etc. in order to detoxify. It is more than 20 poisoning cases observed, the performance of the services poisoning pain, vomiting, diarrhea service, Howl struggle, but not fever. Most deaths within 24 hours, not more than 4 days, such as serving with Tripterygium destroyed within 4 hours after the vomiting agent, laxatives are generally cured.
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